The Health Committee of the Kursk Region and the Ministry of Health referred to the instructions of the Ministry, which states that the usual Sputnik V can be injected through the nose using special nozzles
< img class="aligncenter" src="https://s0.rbk.ru/v6_top_pics/media/img/0/45/756614493676450.jpg" alt="Chief infectious disease specialist explained nasal vaccination with Sputnik in Kursk" />
Vaccine “Sputnik V” in the form of nasal drops does not differ in composition from the drug in the form of a solution for intramuscular injection, Professor Vladimir Chulanov, chief freelance specialist of the Russian Ministry of Health for infectious diseases, told RBC. So he responded to a request to comment on the data that in the Kursk region for nasal vaccination they use not special drops registered in April, but a regular vaccine from the Center. Gamaleya. In particular, Kommersant wrote about this.
Chulanov said that, according to the instructions for Sputnik V, the drug can be administered both intramuscularly and intranasally, using an atomizer nozzle. “Clinical studies have shown a favorable safety and immunogenicity profile, i.e. — the effectiveness of the vaccine both intramuscularly and nasally,», — he pointed out.
According to the chief infectious disease specialist, when administered through the nose, “Sputnik V” forms mucosal immunity (immunity of the mucous membranes of the body) against COVID-19 on the surface of the mucous membrane of the respiratory tract and stimulates the immune response in the regional lymph nodes and tonsils. “This creates a protective barrier to entry gates of infection (nose and oropharynx). It is here that the organism first encounters the virus. Chulanov emphasized.
The Health Committee of the Kursk region also told RBC that the use of “Sputnik V” for nasal vaccination in the region complies with the instructions approved by the Ministry of Health. “It is allowed to administer the vaccine intranasally using a dosing device (spray nozzle on a vertical type syringe on a vertical type syringe for nasal administration of drugs)”, — stated in the current version of the document. It was amended in April 2022.
According to the committee, the health worker decides on the method of vaccination (injectable or intranasal) based on the state of health and the wishes of the patient. When vaccinated through the nose, the drug is administered in two stages with an interval of three weeks, according to the instructions of the Ministry of Health, which the committee handed over to RBC.
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The Ministry registered the nasal vaccine “Gam-COVID-Vac” (Sputnik V), which the agency claims is the world's first vaccine in this format, on April 1. The drug is allowed to be used only for vaccination of patients over 18 years of age. The spray vaccine is the second component of Sputnik V. April 8, the head of the Center. Gamalei Alexander Gintsburg said that the drug was released into civilian circulation and was transported to the regions. In the winter, Gunzburg said that experts did not yet have data on 100% protection with a nasal vaccine, so it was recommended to inject Sputnik V along with it.
In mid-August, the head of the Kursk Health Committee, Ekaterina Pismenny, said that the region was the first in Russia to massively launch nasal vaccination against COVID-19. According to her, the drug in nasal form has been delivered to all medical institutions of the region where vaccination is carried out.
However, Kommersant This week I wrote that during vaccination in the region they use not a nasal, but a regular drug, which is injected into the nose with the help of special nozzles. Nikolai Kryuchkov, an expert in the development and research of drugs, said in a conversation with the publication that from a medical point of view, both a separate vaccine and the usual Sputnik V can be used internally, but legally these are different drugs. “According to the regulatory rules, you can’t just take a vaccine for intramuscular injection, open it, remove the protective cap, change it to a nozzle— and get a new drug, — he said.
In turn, Doctor of Biological Sciences, Professor Konstantin Severinov believes that it is impossible to use a drug intended for intramuscular injection internally: “Any change in the form of drug use will most likely require a dose change. And it needs to be calculated in the course of research.
On August 10, the Ministry of Health announced that the expiration date of Sputnik V extended and range from six months to a year for drugs from different manufacturers. The commentary of the ministry, received by RBC, says: “If the regulator decides to increase the shelf life, this means that the safety, efficacy and quality profile of the drug has not decreased over a certain period of storage.” The department also indicated that, given the short lead times for vaccine development, this practice has been repeatedly used in the European Union and the United States— regions with “strict” regulatory agencies according to the classification of the World Health Organization.
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